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ACVR2A Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P27038 |
| Other Accession | P27038 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57890 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse ACVR2A |
| Epitope Specificity | 1-100/513 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
| SUBUNIT | Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1-6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6). |
| Gene ID | 11480 |
|---|---|
| Other Names | ACVR2; ACTRII; ActrIIa; TactrII; rActR-II; actr2a; acvr2a; wu:fa02e10; AVR2A_HUMAN; Activin receptor type IIA (ACTR-IIA | ACTRIIA); 2.7.11.30; AVR2A_MOUSE; Activin receptor type IIA (ACTR-IIA); AVR2A_RAT; activin A receptor type 2A; activin A receptor, type II; activin A receptor, type IIA |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Acvr2a {ECO:0000312|MGI:MGI:102806} |
|---|---|
| Synonyms | Acvr2 |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Brain, testis, intestine, liver and kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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