癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CENPI Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q92674 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86720 Da |
| Antigen Region | 388-414 aa |
| Gene ID | 2491 |
|---|---|
| Other Names | Centromere protein I, CENP-I, FSH primary response protein 1, Follicle-stimulating hormone primary response protein, Interphase centromere complex protein 19, Leucine-rich primary response protein 1, CENPI, FSHPRH1, ICEN19, LRPR1 |
| Target/Specificity | This CENPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 388-414 amino acids from the Central region of human CENPI. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CENPI Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CENPI |
|---|---|
| Synonyms | FSHPRH1, ICEN19, LRPR1 |
| Function | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle- stimulating hormone. |
| Cellular Location | Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CENPI is involved in the response of gonadal tissues to follicle-stimulating hormone.
REFERENCES
Cheeseman, I.M., et al. Mol. Biol. Cell 19(2):587-594(2008)
Izuta, H., et al. Genes Cells 11(6):673-684(2006)
Okada, M., et al. Nat. Cell Biol. 8(5):446-457(2006)
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