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Bestrophin 4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8NFU0 |
| Other Accession | Q8NFU0 |
| Reactivity | Human |
| Predicted | Pig, Rabbit, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53497 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Bestrophin 4 |
| Epitope Specificity | 151-250/473 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the bestrophin family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina. |
| Gene ID | 266675 |
|---|---|
| Other Names | VMD2L2; BEST4_HUMAN; BEST4; Vitelliform macular dystrophy 2-like protein 2; bestrophin 4; vitelliform macular dystrophy 2-like 2 |
| Target/Specificity | Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta. |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | BEST4 (HGNC:17106) |
|---|---|
| Function | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by Calcium (Ca2+) (PubMed:12907679, PubMed:18400985). Mediates the movement of hydrogencarbonate and chloride (PubMed:12907679, PubMed:18400985). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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