癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C9orf114 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q5T280 |
| Other Accession | Q5T280 |
| Reactivity | Human |
| Predicted | Rat, Pig, Mouse, Rabbit, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42009 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C9orf114 |
| Epitope Specificity | 251-350/376 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | C9orf114 is a 376 amino acid protein encoded by a gene that maps to human chromosome 9q34.11. Chromosome 9 consists of about 145 million bases, represents 4% of the human genome and encodes nearly 900 genes. Thought to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. |
| Gene ID | 51490 |
|---|---|
| Other Names | C9orf114; CENP-32; CENP32; HSPC109; NEDGSB; SPOUT_HUMAN; SPOUT1; Centromere protein 32 (CENP-32); Kinetochore-associated protein; Methyltransferase C9orf114; Ribosomal RNA methyltransferase SPOUT1; SPOUT domain-containing methyltransferase 1; 2.1.1.-; SPOUT_MOUSE; Methyltransferase C9orf114 homolog; D2Wsu81e; SPOUT domain containing methyltransferase 1; chromosome 9 open reading frame 114; centromere protein 32 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SPOUT1 (HGNC:26933) |
|---|---|
| Synonyms | C9orf114 |
| Function | S-adenosyl-L-methionine-dependent RNA methyltransferase (PubMed:39671501, PubMed:39962046). Specifically methylates the N3 position of a uridine in 28S rRNA (PubMed:39671501). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase, ensuring proper spindle organization (PubMed:20813266, PubMed:25657325, PubMed:39962046). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233). |
| Cellular Location | Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the outer kinetochore. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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