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GGT7 heavy chain Rabbit pAb

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, E
Predicted	Rat, Pig, Human, Mouse, Dog, Horse, Sheep
Host	Rabbit
Clonality	Polyclonal
Calculated MW	52 KDa
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human Gamma-glutamyltransferase 7 heavy chain
Epitope Specificity	151-250/662
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SUBCELLULAR LOCATION	Membrane; Single pass type II membrane protein.
SIMILARITY	Belongs to the gamma-glutamyltransferase family.
SUBUNIT	Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Isoform 3 interacts with FAM57A.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008].

Additional Information
Gene ID	2686
Other Names	D20S101; GGT4; GGTL3; GGTL5; gamma-glutamyltransferase 7; gamma-glutamyltransferase-like 3
Target/Specificity	Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.
Dilution	WB=1:500-2000,ELISA=1:5000-10000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Name	GGT7 heavy chain Rabbit pAb
Function	Cleaves glutathione conjugates.