PADI2 Rabbit pAb

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, IHC-F, IF, E
Primary Accession	Q96DA7
Other Accession	Q96DA7
Predicted	Rat, Pig, Human, Mouse, Rabbit, Dog, Horse
Host	Rabbit
Clonality	Polyclonal
Calculated MW	76 KDa
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human PADI2/PAD2
Epitope Specificity	42-120/665
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the protein arginine deiminase family.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Additional Information
Gene ID	11240
Other Names	PAD-H19; PAD2; PDI2; Pdi; mKIAA0994; Q96DA7_HUMAN; PADI2_HUMAN; PADI2; Peptidylarginine deiminase II; Protein-arginine deiminase type II; 3.5.3.15; KIAA0994; PADI2_MOUSE; Q75WD0_MOUSE; PADI2_RAT; peptidyl arginine deiminase 2; peptidyl arginine deiminase, type II
Dilution	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.