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DCUN1D4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q92564 |
| Other Accession | Q92564 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34068 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DCUN1D4 |
| Epitope Specificity | 161-270/292 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 DCUN1 domain |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The DCN1-like protein family is comprised of Dcun1D1, Dcun1D2, Dcun1D3, Dcun1D4 and Dcun1D5. The founding member, Dcun1D1, is involved in the malignant transformation of squamous cell lineage.Dcun1D4, (defective in cullin neddylation protein 1-like protein 4 or DCN1-like protein 4), also designated KIAA0276, exists as 2 isoforms as a result of alternative splicing and contains one DCUN1 domain. The gene encoding Dcun1D4 maps to chromosome 4, which houses nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. |
| Gene ID | 23142 |
|---|---|
| Other Names | DCNL4; RGD1310422; DCNL4_HUMAN; DCUN1D4; DCUN1 domain-containing protein 4; Defective in cullin neddylation protein 1-like protein 4; KIAA0276; DCNL4_MOUSE; Squamous cell carcinoma-related oncogene 4; SCCRO4; defective in cullin neddylation 1 domain containing 4; DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DCUN1D4 (HGNC:28998) |
|---|---|
| Synonyms | KIAA0276 |
| Function | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). |
| Cellular Location | Nucleus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP96235
