癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HHIP Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q96QV1 |
| Other Accession | Q96QV1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 78851 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HHIP |
| Epitope Specificity | 501-600/700 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the HHIP family. Contains 2 EGF-like domains. |
| SUBUNIT | Interacts with all three hedgehog family members, SHH, IHH and DHH. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Hedgehog (Hh) signaling proteins are critical for growth and tissue patterning during development. Patched (Ptc), a putative 12 transmembrane receptor, binds to Sonic hedgehog and is suspected to be a negative regulator of Hh signaling. A family member of patched, designated patched 2, has been found to be co-expressed with Sonic hedgehog. Smoothened (Smo), a seven transmembrane receptor, is complexed with patched in many tissues and is believed to be an essential component in the Hh signaling pathway. Hhip (hedgehog-interacting protein) is able to bind to and may be a transcriptional target of all Hh proteins. Binding of Hhip to Hh proteins attenuates hedgehog signaling. |
| Gene ID | 64399 |
|---|---|
| Other Names | HHIP_HUMAN; HHIP; HIP; HHIP_MOUSE; hedgehog interacting protein; hedgehog-interacting protein |
| Dilution | WB=1:500-2000,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HHIP |
|---|---|
| Synonyms | HIP |
| Function | Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. |
| Cellular Location | Cell membrane; Peripheral membrane protein. Secreted. Note=The last 22 C- terminal amino acids may participate in cell membrane attachment |
| Tissue Location | Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. {ECO:0000269|PubMed:11435703, ECO:0000269|Ref.1} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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