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MARCH10 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8NA82 |
| Other Accession | Q8NA82 |
| Predicted | Rat, Human, Mouse, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 90511 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MARCH10 |
| Epitope Specificity | 711-808/808 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 RING-CH-type zinc finger. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH10 (membrane-associated ring finger (C3HC4) 10), also known as RNF190 (ring finger protein 190) or MARCH-X, is an 808 amino acid protein with one RING-CH-type zinc finger domain. MARCH10 may function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. |
| Gene ID | 162333 |
|---|---|
| Other Names | MARCH-X; MARCH10; RNF190; MARHA_HUMAN; MARCHF10; Membrane-associated RING finger protein 10; Membrane-associated RING-CH protein X (MARCH-X); RING finger protein 190; RING-type E3 ubiquitin transferase MARCHF10; 2.3.2.27; membrane associated ring-CH-type finger 10; membrane-associated ring finger (C3HC4) 10; membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MARCHF10 (HGNC:26655) |
|---|---|
| Synonyms | MARCH10, RNF190 |
| Function | E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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