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Synaptogyrin 3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | O43761 |
| Other Accession | O43761 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24555 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Synaptogyrin 3 |
| Epitope Specificity | 101-200/229 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the synaptogyrin family. Contains 1 MARVEL domain. |
| SUBUNIT | Interacts (via N-terminus) with SLC6A3 (via N-terminus) (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal (Synaptogyrins 1 and 3) and one ubiquitous (Synaptogyrin-2) isoform. Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as Cellugyrin has a tyrosine phosphorylated C-terminal cytoplasmic tail, and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta. The SYNGR4 gene encodes for the 234 amino acid protein Synaptogyrin-4. |
| Gene ID | 9143 |
|---|---|
| Other Names | SNG3_HUMAN; SYNGR3; SNG3_MOUSE; synaptogyrin 3 |
| Dilution | WB=1:500-2000,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SYNGR3 (HGNC:11501) |
|---|---|
| Function | May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R191}; Multi-pass membrane protein. Synapse {ECO:0000250|UniProtKB:Q8R191} Note=Found at the neuromuscular synapses {ECO:0000250|UniProtKB:Q8R191} |
| Tissue Location | Expressed in brain and placenta. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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