癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZFR Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q96KR1 |
| Other Accession | Q96KR1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 117012 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZFR |
| Epitope Specificity | 271-370/1074 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 DZF domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ZFR is 1,074 amino acid RNA-binding protein. In human, ZFR is expressed in lung, liver, lymphocytes, heart, pancreas, kidney and placenta, and regulates postimplantation and gastrulation stages of development. Murine ZFR is observed in testis, ovary and brain. With elevated levels of expression during meiosis, ZFR associates with chromosome foci in meiotic cells. ZFR contains 1 DZF domain and localizes in the somatodendritic compartment of hippocampal neurons and colocalizes with STAU2 in cytosolic RNA granules. Knockout of ZFR in mouse embryo prevents the development of some embryonic structures leads to an increase in programmed cell death with a decrease in mitotic index. |
| Gene ID | 51663 |
|---|---|
| Other Names | SPG71; ZFR1; C920030H05Rik; hnrpa1; wu:fb25b08; zgc:66235; zgc:66403; ZFR_HUMAN; ZFR; hZFR; M-phase phosphoprotein homolog; ZFR_MOUSE; ZFR_RAT; ZFR_DANRE; zinc finger RNA binding protein |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ZFR |
|---|---|
| Function | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Cytoplasmic granule. Chromosome Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity) |
| Tissue Location | Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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