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CRIM-1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9NZV1 |
| Other Accession | Q9NZV1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 113738 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CRIM-1 |
| Epitope Specificity | 641-740/1036 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 4 antistasin-like domains. Contains 1 IGFBP N-terminal domain. Contains 6 VWFC domains. |
| Post-translational modifications | N-glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CRIM1 interacts with BMP4 (bone morphogenic protein 4) and BMP7 and modulates BMP activity by affecting their processing and delivery to the cell surface. By interacting with growth factors implicated in motor neuron differentiation and survival, it may play a role in CNS development. It may also play a role in capillary formation and maintenance during angiogenesis. |
| Gene ID | 51232 |
|---|---|
| Other Names | CRIM-1; S52; CRIM1_HUMAN; CRIM1; Cysteine-rich repeat-containing protein S52; CRIM1_MOUSE; cysteine rich transmembrane BMP regulator 1; cysteine-rich motor neuron 1; cysteine rich transmembrane BMP regulator 1 (chordin-like) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CRIM1 |
|---|---|
| Synonyms | S52 |
| Function | May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. |
| Cellular Location | [Processed cysteine-rich motor neuron 1 protein]: Secreted |
| Tissue Location | Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine Expressed in blood vessels (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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