癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KIAA1211 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZU35 |
| Other Accession | Q6ZU35 |
| Predicted | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 136760 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KIAA1211 |
| Epitope Specificity | 1061-1160/1233 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KIAA1191 is a 305 amino acid protein that belongs to the UPF0498 family and exists as three alternatively spliced isoforms. The gene that encodes KIAA1191 consists of approximately 15,908 bases and maps to human chromosome 5q35.2. With 181 million base pairs, Chromosome 5 comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. |
| Gene ID | 57482 |
|---|---|
| Other Names | 2810489J07Rik; 4930529A19Rik; 4931405B09Rik; C530008M17Rik; Crad; Gm10430; mKIAA1211; CRACD_HUMAN; CRACD; Cancer-related regulator of actin dynamics; KIAA1211; CRACD_MOUSE; capping protein inhibiting regulator of actin dynamics |
| Dilution | WB=1:500-2000,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CRACD (HGNC:29219) |
|---|---|
| Function | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Expressed in intestinal epithelial cells (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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