癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CARD10 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9BWT7 |
| Other Accession | Q9BWT7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 115931 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CARD10 |
| Epitope Specificity | 165-248/248 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 CARD domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Membrane-associated guanylate kinase (MAGUK) family members function as molecular scaffolds for the assembly of multiprotein complexes localizing to the plasma membrane. Several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product belong to the MAGUK family, including the caspase recruitment domain (CARD) protein family with the exception of CARD9. The CARD domain consists of 6 or 7 antiparallel alpha helices. CARD family members participate in apoptosis signaling through highly specific protein-protein homophilic interactions. CARD 10 (also designated CARD-containing MAGUK protein 3 or Carma 3) interacts with BCL-10 to activate NFⅹB. CARD10 is expressed in a variety of adult and fetal tissues, including heart, kidney and liver, and in multiple cancer cell lines. |
| Gene ID | 29775 |
|---|---|
| Other Names | BIMP1; CARMA3; IMD89; caspase recruitment domain family member 10; caspase recruitment domain family, member 10 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CARD10 |
|---|---|
| Synonyms | CARMA3 |
| Function | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96307
