癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RHBG Rabbit pAb
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- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9H310 |
| Other Accession | Q9H310 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49481 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RHBG |
| Epitope Specificity | 331-430/441 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. |
| SUBUNIT | Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane. |
| Post-translational modifications | N-glycosylated. |
| DISEASE | Fetally expressed by kidney and to a lower extent in liver. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| Gene ID | 57127 |
|---|---|
| Other Names | SLC42A2; RHBG_HUMAN; RHBG; Rhesus blood group family type B glycoprotein (Rh family type B glycoprotein | Rh type B glycoprotein); Rh family B glycoprotein; Rhesus blood group, B glycoprotein; Rh family B glycoprotein (gene/pseudogene); solute carrier family 42 member 2 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RHBG (HGNC:14572) |
|---|---|
| Function | Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (PubMed:15284342, PubMed:15929723, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | Specifically expressed in kidney. Also detected in liver and ovary. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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