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alpha Tubulin (Acetyl Lys40) Mouse mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 50 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthesised acetylpeptide derived from human alpha Tubulin around the acetylation site of Acetyl Lys40 |
| Epitope Specificity | SD(Ac-K)TI |
| Isotype | IgG |
| Purity | affinity purified by Protein G |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the tubulin family. |
| SUBUNIT | Dimer of alpha and beta chains. |
| Post-translational modifications | Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable). Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | bs-0159P is one synthetic peptide derived from human Tubulin-alpha 1. Tubulin is a major cytoskeleton that has five distinct forms, designated alpha, beta, gamma, delta and epsilon tubulin. The alpha and beta tubulins form a heterodimer that polymerize into the cylindrical microtubule fibers. Both alpha and beta tubulin bind GTP. Only beta tubulin hydrolyzes GTP to GDP. This hydrolysis is a process that is linked to tubulin polymerization and microtubule formation. The alpha tubulin isomer can be modified by addition of a C-terminal tyrosine residue. This modification may influence polymerization rates. The gamma tubulin isomer is localized to centrosomes which compose the heart of the microtubule organizing center from which microtubule fibers emanate. |
| Other Names | B-ALPHA-1; LIS3; TUBA3; Tuba-1; Tuba1; TBA1A_HUMAN; TUBA1A; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain; 3.6.5.-; TBA1A_MOUSE; Alpha-tubulin 1; Alpha-tubulin isotype M-alpha-1; Tubulin alpha-1 chain; TBA1A_RAT; tubulin alpha 1a; tubulin, alpha, brain-specific; TUBA4A | alpha-Tubulin (acetyl-K40); ac-alpha-Tubulin; acetyl-alpha-Tubulin; ac-Tubulin; TUBA4A | alpha-Tubulin (acetyl-Lys40) |
|---|---|
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | alpha Tubulin (Acetyl Lys40) Mouse mAb |
| Function | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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