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PTPH1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P26045 |
| Other Accession | P26045 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 103990 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PTPH1/PTPN3 |
| Epitope Specificity | 11-110/913 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.Contains 1 FERM domain. Contains 1 PDZ (DHR) domain. Contains 1 tyrosine-protein phosphatase domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. PTP-H1 shares homology with the cytoskeletal-associated proteins band 4.1, ezrin, and talin and has been shown to contain a PDZ and band 4.1 domain. These domains are responsible for targeting proteins to the cytoskeleton-membrane interface, as well as mediating protein-protein interactions, recognizing C-terminal valine residues and binding to other PDZ domains. Overexpression of PTP-H1 may reverse transformation induced by oncogenic protein-tyrosine kinases, such as the members of the src family. |
| Gene ID | 5774 |
|---|---|
| Other Names | PTP-H1; PTPH1; 9530011I20Rik; PTPCL; PTN3_HUMAN; PTPN3; Protein-tyrosine phosphatase H1 (PTP-H1); 3.1.3.48; PTN3_MOUSE; protein tyrosine phosphatase non-receptor type 3 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTPN3 |
|---|---|
| Synonyms | PTPH1 |
| Function | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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