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eRF3/GSPT1 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Reactivity | Human |
| Predicted | Rat, Mouse |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 56 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human eRF3/GSPT1 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the GTP-binding elongation factor family. ERF3 subfamily. |
| SUBUNIT | Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | eRF3a is a 499 amino acid protein that belongs to the GTP-binding elongation factor family and is involved in the regulation of cell growth, specifically via control of translation termination. Human eRF3a shares 94% sequence identity with its mouse counterpart, suggesting a conserved function between species. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. |
| Other Names | 551G9.2; ETF3A; GST1; eRF3a; ERF3A_HUMAN; GSPT1; Eukaryotic peptide chain release factor subunit 3a; G1 to S phase transition protein 1 homolog; 3.6.5.-; G1 to S phase transition 1; eukaryotic release factor 3a |
|---|---|
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | eRF3/GSPT1 Recombinant Rabbit mAb |
| Function | Translation termination in eukaryotes is governed by two proteins, belonging to the class-1 (eRF1) and class-2 (eRF3) polypeptide release factors. eRF3/GSPT1 is involved in regulation of mammalian cell growth and belongs to the GTP-binding elongation factor family (ERF3 subfamily). eRF3 catalyzes hydrolysis of GTP to GDP and inorganic phosphate in the ribosome in the absence of mRNA, tRNA, aminoacyl-tRNA and peptidyl-tRNA. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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