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ZNF451 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y4E5 |
| Other Accession | Q8C0P7 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 121484 Da |
| Antigen Region | 81-110 aa |
| Gene ID | 26036 |
|---|---|
| Other Names | Zinc finger protein 451, Coactivator for steroid receptors, ZNF451, COASTER, KIAA0576, KIAA1702 |
| Target/Specificity | This ZNF451 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human ZNF451. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNF451 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF451 |
|---|---|
| Synonyms | COASTER {ECO:0000303|Ref.1}, KIAA0576, K |
| Function | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). |
| Cellular Location | Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ZNF451 may be involved in transcriptional regulation. Coactivator for steroid receptors
REFERENCES
Karvonen, U., et al. J. Mol. Biol. 382(3):585-600(2008)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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¥ 1,250.00
Cat# AP9637a
