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CEP55 Recombinant Mouse mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Predicted | Human |
| Host | Mouse |
| Clonality | Recombinant |
| Physical State | Liquid |
| Isotype | IgG1, Kappa |
| Purity | affinity purified by Protein G |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBUNIT | Homodimer. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding. Interacts with MVB12A, VPS37B, VPS37C and VPS28. |
| Post-translational modifications | There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CEP55 (Centrosomal protein 55kDa) is essential for mitotic exit and cytokinesis. It is not required for microtubule nucleation. |
| Other Names | C10orf3; CT111; MARCH; URCC6; 1200008O12Rik; 2700032M20Rik; RGD1305340; CEP55_HUMAN; CEP55; Up-regulated in colon cancer 6; CEP55_MOUSE; CEP55_RAT; centrosomal protein 55; chromosome 10 open reading frame 3; centrosomal protein 55kDa; cancer/testis antigen 111 |
|---|---|
| Dilution | WB=1:500-1000,ICC/IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | CEP55 Recombinant Mouse mAb |
| Function | Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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