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DUOXA2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q1HG44 |
| Other Accession | Q1HG44 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34787 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DUOXA2 |
| Epitope Specificity | 251-320/320 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the DUOXA family. |
| Post-translational modifications | N-glycosylated. |
| DISEASE | Defects in DUOXA2 are the cause of thyroid dyshormonogenesis 5 (TDH5) [MIM:274900]. A disorder due to thyroid dyshormonogenesis, causing hypothyroidism, goiter, and variable mental deficits derived from unrecognized and untreated hypothyroidism |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | DUOXA2 is a 320 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum (ER) and belongs to the DUOXA family. Expressed specifically in thyroid and salivary glands, DUOXA2 is essential for the maturation and transport of DUOX2 from the ER to the plasma membrane and is also thought to play a role in the synthesis of thyroid hormone (TH). Defects in the DUOXA2 gene are associated with the pathogenesis of congenital hypothyroidism, a disorder that affects infants and is characterized by a significant decrease or a complete deficiency of TH from birth. The gene encoding DUOXA2 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. |
| Gene ID | 405753 |
|---|---|
| Other Names | SIMNIPHOM; TDH5; DOXA2_HUMAN; DUOXA2; Dual oxidase activator 2; dual oxidase maturation factor 2 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DUOXA2 |
|---|---|
| Function | Required for the maturation and transport of functional DUOX2 from the endoplasmic reticulum to the plasma membrane (PubMed:16651268). Recruits DUOX2 to the apical cell membrane (PubMed:39126279). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein |
| Tissue Location | Specifically expressed in thyroid. Also detected in salivary glands. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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