癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Bex1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9HBH7 |
| Other Accession | Q9HBH7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 14860 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HBEX2/Bex1 |
| Epitope Specificity | 55-125/125 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the BEX family. |
| SUBUNIT | Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity). |
| Post-translational modifications | Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity). Ubiquitinated. Degraded by the proteasome (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The brain-expressed X-linked (Bex) family of proteins is expressed in the central nervous system, with highest levels detected in cerebellum, temporal lobe and pituitary tissues. Bex1 plays an important role in neuronal differentiation in response to nerve growth factor (NGF), as well as in cell cycle progression. Bex1 is a highly ubiquitinated protein and acts as a link between the cell cycle and neurotrophic factor signaling. Bex2 interacts with LMO2, thereby regulating the transcriptional activity of a DNA-binding complex. Bex1 and Bex 2 are widely expressed outside of the central nervous system with high expression in the liver. Bex1 and Bex2 shuttle between the cytoplasm and the nucleus. Though the role of Bex1 is largely unknown, it may function by coordinating internal cellular states with the ability of cells to respond to external signals. |
| Gene ID | 55859 |
|---|---|
| Other Names | BEX2; HBEX2; HGR74-h; BEX1_HUMAN; BEX1; Brain-expressed X-linked protein 1; brain expressed X-linked 1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | BEX1 |
|---|---|
| Function | Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q3MKQ2}. Cytoplasm {ECO:0000250|UniProtKB:Q3MKQ2}. Note=Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. {ECO:0000250|UniProtKB:Q3MKQ2} |
| Tissue Location | Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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