癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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SEL1L Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q12916 |
| Other Accession | Q12916 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 89 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SEL1L |
| Epitope Specificity | 151-250/794 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the sel-1 family.Contains 1 fibronectin type-II domain.Contains 11 Sel1-like repeats. |
| SUBUNIT | Part of a complex containing SEL1L, SYVN1 and DERL2. May form a complex with ERLEC1, HSPA5, OS9, and SYVN1. Interacts with FOXRED2 and EDEM1. |
| Post-translational modifications | N-glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SEL1L, highly similar to the C elegans sel-1 gene, is a recently cloned human gene whose function is under investigation. SEL1L is differentially expressed in tumors and normal tissues and seems to play a role in tumor growth and aggressiveness. It may be an important negative regulator of the "notch" pathway which acts as a key regulator of the cellular proliferation and specification processes in both vertebrates and invertebrates. SEL1L may function in the protein degradation processes through the ubiquitin-proteosome system and perhaps in regulating important pathways such TGF-beta. It is ubiquitously expressed only in fetal and neoplastic tissues. In normal adult tissues is highly expressed in the acini and in the alpha cells of the pancreas; in general it is highly represented in secretory cells such as plasma cells. |
| Gene ID | 6400 |
|---|---|
| Other Names | Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE; SEL1L1; Sel1h; mKIAA4137; Sel1l; Q12916_HUMAN; SE1L1_HUMAN; Suppressor of lin-12-like protein 1 (Sel-1L); TSA305; SE1L1_MOUSE; SE1L1_RAT; SEL1L adaptor subunit of SYVN1 ubiquitin ligase; sel-1 suppressor of lin-12-like (C. elegans); SEL1L, ERAD E3 ligase adaptor subunit; SEL1L adaptor subunit of ERAD E3 ubiquitin ligase; sel-1 suppressor of lin-12-like 1 (C. elegans) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SEL1L Rabbit pAb |
|---|---|
| Function | May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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