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phospho-MAP4 (Ser1046) Rabbit pAb
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- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P27546 |
| Other Accession | P27546 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 117429 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthesised phosphopeptide derived from mouse MAP4 around the phosphorylation site of Ser1046 |
| Epitope Specificity | VG(p-S)LD |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 4 Tau/MAP repeats. |
| SUBUNIT | Interacts with SEPT2; this interaction impedes tubulin-binding (By similarity). |
| Post-translational modifications | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-760 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 4 is phosphorylated on Ser-333 and Ser-334 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The MAP4 (Microtubule associated protein 4)is a non neuronal microtubule associated protein. It promotes microtubule assembly.The phosphorylation of the Pro rich region in the C-terminus negatively regulates MAP4 activity to promote microtubule assembly. |
| Gene ID | 17758 |
|---|---|
| Other Names | MAP-4; Mtap-4; Mtap4; MAP4_HUMAN; MAP4; MAP4_MOUSE; MAP4_RAT; microtubule associated protein 4; MAP4 (phospho-S1046); p-MAP4; phospho-MAP4; MAP4 (phospho-Ser1046) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Map4 |
|---|---|
| Synonyms | Mtap4 |
| Function | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P27816}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:P27816}. Note=Recruitment to microtubule is inhibited by microtubules polyglutamylation {ECO:0000250|UniProtKB:P27816} |
| Tissue Location | Testis, striated and cardiac muscle. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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