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HIF1AN Mouse mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q5W147 |
| Other Accession | Q5W147 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 38 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HIF1AN |
| Epitope Specificity | 1-349/349 |
| Isotype | IgG1, k |
| Purity | affinity purified by Protein G |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 JmjC domain. |
| SUBUNIT | Homodimer; homodimerization is essential for catalyticactivity. Interacts with VHL and HIF1A. Part of a complex with VHL,HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA.Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4.Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A.Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4(By similarity). Interacts with UBE3A. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | HIF1AN (Hypoxia inducible factor 1 alpha inhibitor) is a corepressor that interacts with hypoxia inducible factor 1 (HIF1) alpha and the von Hippel Lindau tumor suppressor protein to mediate repression of HIF1 transcriptional activity. |
| Gene ID | 55662 |
|---|---|
| Other Names | FIH1; Q5W147_HUMAN; HIF1N_HUMAN; HIF1AN; Factor inhibiting HIF-1 (FIH-1); Hypoxia-inducible factor asparagine hydroxylase; 1.14.11.30; 1.14.11.n4; hypoxia inducible factor 1 subunit alpha inhibitor; Peptide-aspartate beta-dioxygenase |
| Dilution | WB=1:1000-5000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HIF1AN Mouse mAb |
|---|---|
| Function | Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96538
