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phospho-ASAP1 (Tyr782) Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9QWY8 |
| Other Accession | Q9QWY8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 127421 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated Synthesised phosphopeptide derived from mouse DDEF1 around the phosphorylation site of Tyr782 |
| Epitope Specificity | LS(p-Y)GA |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain. Contains 1 SH3 domain. |
| SUBUNIT | Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2. Interacts with CTTN. Interacts (via SH3 domain) with APC. |
| Post-translational modifications | Phosphorylated on tyrosine residues by SRC |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| Gene ID | 13196 |
|---|---|
| Other Names | AMAP1; CENTB4; DDEF1; PAG2; PAP; ZG14P; DEF-1; ASAP1_BOVIN; ASAP1; 130 kDa phosphatidylinositol 4, 5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1 (ARF GTPase-activating protein 1); Development and differentiation-enhancing factor 1 (DEF-1 | Differentiation-enhancing factor 1); PIP2-dependent ARF1 GAP; ASAP1_HUMAN; KIAA1249; ASAP1_MOUSE; Shag1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1; development and differentiation enhancing factor 1; centaurin, beta 4; ASAP1 (phospho-Y782); p-ASAP1; phospho-ASAP1; ASAP1 (phospho-Tyr782) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Asap1 |
|---|---|
| Synonyms | Ddef1, Kiaa1249, Shag1 |
| Function | May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity). |
| Cellular Location | Cytoplasm. Membrane. Golgi apparatus {ECO:0000250|UniProtKB:Q9ULH1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9ULH1}. Note=Predominantly cytoplasmic Partially membrane-associated |
| Tissue Location | Expressed in all tissues examined but a most abundant expression was found in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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