癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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GOT1L1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8NHS2 |
| Other Accession | Q8NHS2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47305 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GOT1L1 |
| Epitope Specificity | 201-300/421 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
| SUBUNIT | Homodimer (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GOT1L1, Glutamate oxaloacetate transaminase 1-like protein 1, is a 421 amino acid member of the class-I pyridoxal-phosphate-dependent aminotransferase family. Similar to glutamate-oxaloacetate transaminase (GOT1), GOT1L1 is found primarily as a homodimer in the cytoplasmic space but also has mitochondrial and chloroplastic isozymes. GOT1L1 transaminates 2-oxoglutarate with L-aspartate to yield oxaloacetate and L-glutamate. This reaction requires a pyridoxal phosphate cofactor to occur. The GOT1L1 peptidase is predominately expressed in the liver and serum levels of this protein can be used as an indicator of liver disease. Also, elevated glutamate concentrations in the brain interstitial fluids can lead to pathological brain conditions. The glutamate-scavenging properties of these aminotranferase type enzymes likely prevent glutamate excitotoxicity and the long-lasting neurological deficits seen after stroke. |
| Gene ID | 137362 |
|---|---|
| Other Names | 1700083M11Rik; AATC2_HUMAN; GOT1L1; Glutamate oxaloacetate transaminase 1-like protein 1; Transaminase A-like protein 1; 2.6.1.1; AATC2_MOUSE; glutamic-oxaloacetic transaminase 1 like 1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GOT1L1 (HGNC:28487) |
|---|---|
| Function | Catalyzes the conversion of L-aspartate and 2-oxoglutarate to L-glutamate and oxaloacetate (PubMed:25287256). It has been proposed to exhibit aspartate racemase activity, but this function remains debated and lacks strong experimental support (PubMed:25287256). |
| Cellular Location | Cytoplasm. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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