癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DDX3Y Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O15523 |
| Other Accession | O15523 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73154 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from Human DDX3Y |
| Epitope Specificity | 401-500/660 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
| SUBUNIT | May interact with TDRD3. |
| DISEASE | Note=DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | DDX3X is encoded by a gene found on the X chromosome while DDX3Y is encoded by a gene on the Y chromosome. DDX3Y is exclusively expressed in testis and is required for normal spermatogenesis. DDX3X is ubiquitously expressed and predominantly localizes to the nuclear speckles, participating in RNA splicing, transcription, translation initiation, mRNA transport and cell cycle regulation. DDX3X also partakes in HIV-1 replication and hepatitis C viral infections. |
| Gene ID | 8653 |
|---|---|
| Other Names | DBY; 8030469F12Rik; D1Pas1-rs1; Ddx3; DDX3Y_HUMAN; DDX3Y; DEAD box protein 3, Y-chromosomal; 3.6.4.13; DDX3Y_MOUSE; D1Pas1-related sequence 1; DEAD-box RNA helicase DEAD2 (mDEAD2); Dead2; DEAD-box helicase 3 Y-linked; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DDX3Y |
|---|---|
| Function | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). |
| Cellular Location | Cytoplasm. Nucleus Note=Shuttles between the nucleus and the cytoplasm in an XPO1- dependent manner |
| Tissue Location | Widely expressed at the mRNA level, with highest levels in testis (PubMed:9381176). Testis-specific (at protein level) Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes (PubMed:15294876) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
