癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Dysferlin interacting protein 1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q86WC6 |
| Other Accession | Q86WC6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17438 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Dysferlin interacting protein 1 |
| Epitope Specificity | 7-100/154 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 2 ANK repeats. |
| SUBUNIT | Interacts with DYSF and PPP1CA. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Dysferlin is a muscle-specific protein that is essential for normal muscle function and development (1). Mutations in the human dysferlin gene, DYSF, which maps to chromosome 2p13.3-p13.1, are associated with limb girdle muscular dystrophy-2B (LGMD-2B) and a related, adult-onset, distal dystrophy known as Miyoshi myopathy (MM) (1,2). Dysferlin localizes to the muscle fiber membrane, but is absent in MM and LGMD-2B muscle (1,3). Dysferlin is detected in 5-6 week embryos, when limbs begin to form regional differentiation (3). Although it is not essential for initial myogenesis, dysferlin appears to be critical for sustained normal function in mature muscle (1). It has been suggested that the absence of dysferlin during development gives rise to the disease phenotype in adulthood (3). Identical mutations in the dysferlin gene can produce more than one myopathy phenotype, indicating that additional genes and/or other factors are also involved in the clinical phenotype (4,5). The DYSF gene has no homology to any other known mammalian gene, but the protein product is related to the spermatogenesis factor fer-1 of Caenorhabditis elegans. The name ‘dysferlin’ combines the role of the gene in producing muscular dystrophy with its homology to C. elegans (6). |
| Gene ID | 116729 |
|---|---|
| Other Names | DYSFIP1; 1110033I14Rik; toonin; RGD1308861; PPR27_HUMAN; PPP1R27; Dysferlin-interacting protein 1; PPR27_MOUSE; protein phosphatase 1 regulatory subunit 27; dysferlin-interacting protein 1 (toonin); dysferlin interacting protein 1 (toonin); dysferlin interacting protein 1; protein phosphatase 1, regulatory subunit 27 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PPP1R27 |
|---|---|
| Synonyms | DYSFIP1 |
| Function | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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