癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C3orf33 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q6P1S2 |
| Other Accession | Q6P1S2 |
| Reactivity | Human |
| Predicted | Rat, Pig, Mouse, Rabbit, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33765 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C3orf33 |
| Epitope Specificity | 151-250/294 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | C3orf33, also known as FLJ31139, is a 294 amino acid single-pass membrane protein encoded by a gene that maps to human chromosome 3q25.31. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3. |
| Gene ID | 285315 |
|---|---|
| Other Names | AC3-33; CC033_HUMAN; C3orf33; Protein AC3-33; |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MISO1 (HGNC:26434) |
|---|---|
| Function | Regulates mitochondrial morphology and mitochondrial DNA (mtDNA) homeostasis (PubMed:41398051). Promotes the formation of specialized mitochondrial subdomains called small MTFP1-enriched mitochondria (SMEM) (PubMed:41398051). Negatively regulates mitochondrial fusion by excluding fusion coordinator OPA1 from SMEM (PubMed:41398051). Recruits mtDNA, potentially through interaction with SSBP1, and facilitates mtDNA transport to the mitochondrial periphery (PubMed:41398051). Also recruits other proteins, including PHB1, PHB2 and MTFP1, into SMEM which promotes peripheral mitochondrial fission, facilitating lysosome-mediated clearance of damaged mtDNA via mitophagy (PubMed:41398051). |
| Cellular Location | [Isoform 1]: Mitochondrion inner membrane; Single-pass membrane protein. Note=Assembles into discrete subdomains known as small MTFP1-enriched mitochondria (SMEM). |
| Tissue Location | Highly expressed in ileocecal tissue and endometrium. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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