癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Arginase 1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q61176 |
| Other Accession | Q61176 |
| Reactivity | Human |
| Predicted | Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34808 Da |
| Physical State | Liquid |
| Immunogen | Recombinant mouse Arginase 1 protein |
| Epitope Specificity | 1-291/323 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the arginase family. |
| SUBUNIT | Homotrimer. |
| DISEASE | Defects in ARG1 are the cause of argininemia (ARGIN) ; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Arginase I which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea . The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence. |
| Gene ID | 11846 |
|---|---|
| Other Names | AI; Arg-1; PGIF; ARGI1_BOVIN; ARG1; Liver-type arginase; Type I arginase; 3.5.3.1; ARGI1_HUMAN; ARGI1_MOUSE; ARGI1_PIG; ARGI1_RABIT; ARGI1_RAT; arginase 1; arginase, liver; arginase-1 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Arg1 |
|---|---|
| Function | Catalyzes the final step of the urea cycle by hydrolyzing L- arginine into urea, a nitrogenous waste product, and L-ornithine, a precursor to proline and polyamines; the urea cycle occurs primarily in the liver and, to a lesser extent, in the kidneys. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05089}. Cytoplasmic granule {ECO:0000250|UniProtKB:P05089}. Note=Localized in azurophil granules of neutrophils. {ECO:0000250|UniProtKB:P05089} |
| Tissue Location | Expressed in macrophages (PubMed:12193690, PubMed:19360123, PubMed:7537672). Expressed in precursor and mature group 2 innate lymphoid cells (ILC2s) (PubMed:27043409). Expressed in lung tumor-associated myeloid cells (PubMed:15313928). Expressed in lung tumor-infiltrating dendritic cells (PubMed:19414774) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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