癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
S100A11 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P31949 |
| Other Accession | P31949 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 11740 Da |
| Physical State | Liquid |
| Immunogen | Recombinant human S100A11 protein |
| Epitope Specificity | 1-105/105 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the S-100 family.Contains 2 EF-hand domains. |
| SUBUNIT | Homodimer; disulfide-linked. |
| Post-translational modifications | Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq] |
| Gene ID | 6282 |
|---|---|
| Other Names | HEL-S-43; MLN70; S100C; S10AB_HUMAN; S100A11; Calgizzarin; Metastatic lymph node gene 70 protein (MLN 70); Protein S100-C; S100 calcium-binding protein A11; S100 calcium binding protein A11; S100 calcium-binding protein A11 (calgizzarin) |
| Dilution | WB=1:500-2000,ICC/IF=1:50-200 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | S100A11 |
|---|---|
| Synonyms | MLN70, S100C |
| Function | Facilitates the differentiation and the cornification of keratinocytes. |
| Cellular Location | Cytoplasm. Nucleus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96632
