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Myosin Light Chain 2 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Reactivity | Mouse |
| Predicted | Rat, Human |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 20 KDa |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human Myosin light chain 2 |
| Epitope Specificity | 100-166/166 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 3 EF-hand domains. |
| SUBUNIT | Myosin is a hexamer of 2 heavy chains and 4 light chains. |
| Post-translational modifications | N-terminus is methylated by METTL11A/NTM1. |
| DISEASE | Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
| Other Names | MLC-2s/v; CMH10; MFM12; MLC-2; MLC-2v; MLC2; Gm32672; Mlc2v; Mylpc; MLRV_BOVIN; MYL2; Myosin light chain 2, slow skeletal/ventricular muscle isoform (MLC-2s/v); MLRV_HUMAN; Cardiac myosin light chain 2; Ventricular myosin light chain 2; MLRV_MOUSE; MLRV_RAT; myosin light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow; myosin, light chain 2, regulatory, cardiac, slow; cardiac ventricular myosin light chain 2 |
|---|---|
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | Myosin Light Chain 2 Recombinant Rabbit mAb |
| Function | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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