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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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delta 2 Catenin Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O35927 |
| Other Accession | O35927 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 135000 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from mouse delta 2 Catenin |
| Epitope Specificity | 10-74 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Belongs to the beta-catenin family. Contains 9 ARM repeats. |
| SUBUNIT | Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). |
| Post-translational modifications | O-glycosylated. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of canonical Wnt signaling.It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. |
| Gene ID | 18163 |
|---|---|
| Other Names | GT24; NPRAP; CTND2_HUMAN; CTNND2; Delta-catenin; Neural plakophilin-related ARM-repeat protein (NPRAP); Neurojungin; CTND2_RAT; CTND2_MOUSE; Catnd2; catenin delta 2; catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); catenin (cadherin-associated protein), delta 2; neural plakophilin-related arm-repeat protein |
| Dilution | WB=1:500-2000,ICC/IF=1:50-200,Flow-Cyt=1:50-100 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ctnnd2 |
|---|---|
| Synonyms | Catnd2, Nprap |
| Function | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:17993462, PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta- catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (PubMed:15282317). |
| Cellular Location | Nucleus. Cell junction, adherens junction. Cell projection, dendrite {ECO:0000250|UniProtKB:O35116}. Perikaryon {ECO:0000250|UniProtKB:O35116} |
| Tissue Location | Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions Expressed at neuromuscular junctions. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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