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phospho-ASC (Tyr144) Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21 KDa |
| Physical State | Liquid |
| Immunogen | Asc (Tyr144) phospho-peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-144 in mouse Asc. This peptide sequence is highly conserved in human and rat Asc. |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| SIMILARITY | Contains 1 CARD domain.Contains 1 DAPIN domain. |
| SUBUNIT | Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PYDC1. |
| Post-translational modifications | Phosphorylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Tissue specificity: Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. |
| Other Names | ASC; CARD5; TMS; TMS-1; TMS1; ASC_HUMAN; PYCARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1; PYD and CARD domain containing; apoptosis-associated speck-like; apoptosis-associated speck-like protein containing a CARD; Caspase, PYCARD, AIM, ASC, CARD5, TMS1 |
|---|---|
| Dilution | WB=1:300-5000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | phospho-ASC (Tyr144) Rabbit pAb |
| Function | Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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