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GAD65 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P48320 |
| Other Accession | P48320 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 65224 Da |
| Physical State | Liquid |
| Immunogen | Recombinant mouse GAD65 protein |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the group II decarboxylase family. |
| SUBUNIT | Homodimer. |
| Post-translational modifications | Phosphorylated; which does not affect kinetic parameters or subcellular location. Palmitoylated; which is required for presynaptic clustering. |
| Background Descriptions | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008] |
| Gene ID | 14417 |
|---|---|
| Other Names | GAD65; 6330404F12Rik; GAD(65); Gad-2; DCE2_HUMAN; GAD2; 65 kDa glutamic acid decarboxylase (GAD-65); Glutamate decarboxylase 65 kDa isoform; 4.1.1.15; DCE2_MOUSE; DCE2_RAT; glutamate decarboxylase 2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) |
| Dilution | WB=1:500-2000,IF=1:200-800,IHC-P=1:200-800,IHC-F=1:200-800 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Gad2 |
|---|---|
| Synonyms | Gad65 |
| Function | Catalyzes the production of GABA. |
| Cellular Location | Cytoplasm, cytosol. Cytoplasmic vesicle. Presynaptic cell membrane; Lipid- anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters (By similarity). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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