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HIF Prolyl Hydroxylases Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9NXG6 |
| Other Accession | Q9NXG6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56661 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HIF Prolyl Hydroxylases |
| Epitope Specificity | 201-300/502 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 2 EF-hand domains. Contains 1 Fe2OG dioxygenase domain. |
| SUBUNIT | Homodimer. |
| Post-translational modifications | Glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. |
| Gene ID | 54681 |
|---|---|
| Other Names | PH-4; EGLN4; HIDEA; HIFPH4; P4H-TM; PH4; PHD4; 4933406E20Rik; HIF-PH4; HPH-4; RGD1311848; P4HTM_HUMAN; P4HTM; Hypoxia-inducible factor prolyl hydroxylase 4 (HIF-PH4 | HIF-prolyl hydroxylase 4 | HPH-4); 1.14.11.29; P4HTM_MOUSE; prolyl 4-hydroxylase, transmembrane; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain-containing 4; hypoxia inducible factor prolyl 4 hydroxylase |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | P4HTM |
|---|---|
| Synonyms | PH4 |
| Function | Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
| Tissue Location | Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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