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CTDSPL Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O15194 |
| Other Accession | O15194 |
| Reactivity | Rat, Human, Mouse |
| Predicted | Pig, Rabbit, Chicken, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31129 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SCP3 |
| Epitope Specificity | 145-250/276 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 FCP1 homology domain. |
| SUBUNIT | Monomer. Interacts with REST. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. |
| Gene ID | 10217 |
|---|---|
| Other Names | C3orf8; HYA22; PSR1; RBSP3; SCP3; 2810418J22Rik; CTDSL_HUMAN; CTDSPL; CTDSP-like; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; Nuclear LIM interactor-interacting factor 1 (NLI-interacting factor 1); Protein YA22 (hYA22); Small C-terminal domain phosphatase 3 (SCP3 | Small CTD phosphatase 3); 3.1.3.16; NIF1; NIFL; YA22; CTDSL_MOUSE; CTSL2_RAT; Ctdspl2; CTDSP-like 2; 3.1.3.-; CTD small phosphatase like; chromosome 3 open reading frame 8; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; small CTD phosphatase 3; HYA22 protein; RB protein serine phosphatase from chromosome 3 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CTDSPL |
|---|---|
| Synonyms | C3orf8, NIF1, NIFL, SCP3, YA22 |
| Function | Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. |
| Cellular Location | Nucleus. |
| Tissue Location | Expression is restricted to non-neuronal tissues. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96744
