癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLEC7A Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q6QLQ4 |
| Other Accession | Q6QLQ4 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27420 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse CLEC7A |
| Epitope Specificity | 31-130/244 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 C-type lectin domain. |
| SUBUNIT | Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens. |
| Post-translational modifications | on tyrosine residues in response to glucan binding. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq]. |
| Other Names | BGR; CANDF4; CD369; CLECSF12; DECTIN1; SCARE2; beta-GR; Clec7b; RGD1565140; CLC7A_HUMAN; CLEC7A; Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1 (DC-associated C-type lectin 1 | Dectin-1); CLC7A_MOUSE; C-type lectin domain containing 7A; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7, member A; C-type lectin domain family 7 member A |
|---|---|
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Clec7a {ECO:0000312|MGI:MGI:1861431} |
|---|---|
| Function | Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11544516, PubMed:15213161, PubMed:17159984). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:12719479, PubMed:15731053, PubMed:16825490, PubMed:32358020). Enhances cytokine production in macrophages and dendritic cells (PubMed:15845454). Mediates production of reactive oxygen species in the cell (PubMed:12719479, PubMed:15731053, PubMed:16825490). Mediates phagocytosis of C.albicans conidia (PubMed:15729357, PubMed:16825490). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation (PubMed:10779524). Stimulates T-cell proliferation (PubMed:10779524). Induces phosphorylation of SCIMP after binding beta-glucans (PubMed:27288407). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein Note=Enriched on zymosan phagosomes. Enrichment does not depend on opsonization |
| Tissue Location | Detected in spleen (at protein level). Highly expressed in dendritic cells, spleen and thymus. Detected in epidermal Langerhans cells. Detected in macrophages, liver and lung |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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