癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DPEP3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9H4B8 |
| Other Accession | Q9H4B8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53687 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DPEP3 |
| Epitope Specificity | 301-400/488 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the peptidase M19 family. |
| SUBUNIT | Homodimer; disulfide-linked (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a membrane-bound glycoprotein from thefamily of dipeptidases involved in hydrolytic metabolism of variousdipeptides, including penem and carbapenem beta-lactam antibiotics.This gene is located on chromosome 16 in a cluster with anothermember of this family. Alternatively spliced transcript variantsthat encode different isoforms have been found for this gene.[provided by RefSeq, Jul 2008]. |
| Gene ID | 64180 |
|---|---|
| Other Names | MBD3; 1700018F16Rik; MBD-3; MLZ-136; DPEP3_HUMAN; DPEP3; DPEP3_MOUSE; Membrane-bound dipeptidase 3 (MBD-3); Protein expressed in male leptotene and zygotene spermatocytes 136 (MLZ-136); dipeptidase 3 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DPEP3 |
|---|---|
| Function | Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (PubMed:32325220). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9DA79}; Lipid- anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9DA79} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96813
