癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SOCS6 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O14544 |
| Other Accession | O14544 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59528 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SOCS6 |
| Epitope Specificity | 21-120/535 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 SH2 domain. Contains 1 SOCS box domain. |
| SUBUNIT | Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Interacts with KIT (phosphorylated). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]. |
| Gene ID | 9306 |
|---|---|
| Other Names | CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6; SOCS4; SSI4; STAI4; STATI4; 1500012M23Rik; 5830401B18Rik; Cish4; SOCS6_HUMAN; SOCS6; Cytokine-inducible SH2 protein 4 (CIS-4); Suppressor of cytokine signaling 4 (SOCS-4); SOCS6_MOUSE; suppressor of cytokine signaling 6; suppressor of cytokine signaling 4 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SOCS6 |
|---|---|
| Synonyms | CIS4, SOCS4 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96816
