癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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SNRP70 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P08621 |
| Other Accession | P08621 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51557 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SNRP70 |
| Epitope Specificity | 101-200/437 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 RRM (RNA recognition motif) domain. |
| SUBUNIT | U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SCNM1. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2. |
| Post-translational modifications | The N-terminus is blocked. Extensively phosphorylated on serine residues in the C-terminal region. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SNRP70 is an RNA-binding protein that is a specific component of the U1 small nuclear ribonucleoprotein complex and constitutes the major anti-(U1) RNP autoimmune antigen. SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. |
| Gene ID | 6625 |
|---|---|
| Other Names | RNPU1Z; RPU1; SNRP70; Snp1; U1-70K; U170K; U1AP; U1RNP; 2700022N21Rik; 3200002N22Rik; Rnu1p70; Rnulp70; Srnp70; U1-70; RU17_HUMAN; SNRNP70; U1 snRNP 70 kDa; U1AP1; RU17_MOUSE; small nuclear ribonucleoprotein U1 subunit 70; small nuclear ribonucleoprotein 70kDa (RNP antigen); small nuclear ribonucleoprotein 70kDa (U1); small nuclear ribonucleoprotein, U1 70kDa subunit |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SNRNP70 |
|---|---|
| Synonyms | RNPU1Z, RPU1, SNRP70, U1AP1 |
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). |
| Cellular Location | Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250|UniProtKB:Q62376} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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