癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEM120A Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8C1E7 |
| Other Accession | Q8C1E7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40751 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse TMEM120A |
| Epitope Specificity | 251-343/343 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Belongs to the TMEM120 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 215210 |
|---|---|
| Other Names | NET29; TACAN; TMPIT; 2010310D06Rik; RGD1311474; TACAN_BOVIN; TMEM120A; Ion channel TACAN; TACAN_HUMAN; Protein TACAN; Transmembrane protein induced by tumor necrosis factor alpha; TACAN_MOUSE; TACAN_RAT; transmembrane protein 120A |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Tmem120a {ECO:0000303|PubMed:26024229, ECO:0000312|MGI:MGI:2686991} |
|---|---|
| Function | Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation (PubMed:26024229, PubMed:32084332, PubMed:34731626, PubMed:35027552, PubMed:39147733). May function as a potential ion channel involved in sensing mechanical stimuli (By similarity). Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction (By similarity). TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (PubMed:35819364, PubMed:39147733). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism (PubMed:34374644). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXJ8}. Nucleus envelope. Nucleus inner membrane {ECO:0000250|UniProtKB:Q9BXJ8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXJ8}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9BXJ8} |
| Tissue Location | Widely expressed, with higher expression in the heart, kidneys, colon and sensory neurons of the dorsal root ganglia (PubMed:32084332). Expressed in nociceptors (PubMed:32084332). Highly expressed in white adipose tissue (at protein level) (PubMed:26024229) Highly expressed in brown adipose tissue and expressed at low levels in liver (PubMed:26024229). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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