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MAML3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q96JK9 |
| Other Accession | Q96JK9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 122293 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MAML3 |
| Epitope Specificity | 931-1030/1134 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the mastermind family. |
| SUBUNIT | Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The three MAML genes are widely expressed in adult tissues but exhibit distinct expression patterns in mouse early spinal cord development. All MAML proteins localize to nuclear bodies, share a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch, and contain a transcriptional activation domain in their C termini. MAML3 acts as a transcriptional coactivator for NOTCH proteins and has been shown to amplify NOTCH-induced transcription of HES1. |
| Gene ID | 55534 |
|---|---|
| Other Names | CAGH3; ERDA3; GDN; MAM-2; MAM2; TNRC3; mam-3; MAML3_HUMAN; MAML3; KIAA1816; mastermind like transcriptional coactivator 3; trinucleotide repeat containing 3; mastermind-like 3 (Drosophila); mastermind (drosophila)-like 3 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAML3 (HGNC:16272) |
|---|---|
| Function | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. |
| Cellular Location | Nucleus speckle. Note=Nuclear, in a punctate manner |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96903
