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SUR1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q09428 |
| Other Accession | Q09428 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 176992 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SUR1 |
| Epitope Specificity | 301-400/1581 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.Contains 2 ABC transmembrane type-1 domains.Contains 2 ABC transporter domains. |
| SUBUNIT | Interacts with KCNJ11. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene. |
| Gene ID | 6833 |
|---|---|
| Other Names | ABC36; HHF1; HI; HRINS; MODY12; MRP8; PHHI; PNDM3; SUR; SUR1; SUR1delta2; TNDM2; D930031B21Rik; ABCC8_HUMAN; ABCC8; Sulfonylurea receptor 1; ABCC8_RAT; ATP binding cassette subfamily C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; sulfonylurea receptor (hyperinsulinemia) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ABCC8 |
|---|---|
| Synonyms | HRINS, SUR, SUR1 |
| Function | Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP96909
