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Sema3A Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q14563 |
| Other Accession | Q14563 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human, Rabbit, Chicken, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 88889 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Sema3A |
| Epitope Specificity | 111-210/772 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 PSI domain. Contains 1 Sema domain. |
| SUBUNIT | Interacts with PXND1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. |
| Gene ID | 10371 |
|---|---|
| Other Names | COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMAD; SEMAIII; SEMAL; SemD; coll-1; SEM3A_HUMAN; SEMA3A; Semaphorin III (Sema III); SEM3A_MOUSE; Semaphorin-D (Sema D); Q5BL08_MOUSE; SEM3A_RAT; semaphorin 3A; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; sema III |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SEMA3A |
|---|---|
| Synonyms | SEMAD |
| Function | Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in the dorsal root ganglia. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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