COMMD9 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	Q9P000
Other Accession	Q9P000
Host	Rabbit
Clonality	Polyclonal
Calculated MW	21819 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human COMMD9
Epitope Specificity	11-100/198
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SIMILARITY	Contains 1 COMM domain.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	COMMD9 (COMM domain containing 9) is a 198 amino acid ubiquitously expressed protein that contains one COMM domain and may be involved in signaling events throughout the cell. The gene encoding COMMD9 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Additional Information
Gene ID	29099
Other Names	C11orf55; HSPC166; LINC00610; COMD9_HUMAN; COMMD9; COMM domain containing 9
Dilution	WB=1:500-2000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	COMMD9
Function	Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin- RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down- regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).
Cellular Location	Nucleus. Cytoplasmic vesicle
Tissue Location	Ubiquitous..