癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTPLB Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6Y1H2 |
| Other Accession | Q6Y1H2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28368 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PTPLB |
| Epitope Specificity | 181-254/254 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Belongs to the very long-chain fatty acids dehydratase HACD family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016] |
| Gene ID | 201562 |
|---|---|
| Other Names | PTPLB; 6330408J20Rik; Hcad2; HACD2_HUMAN; HACD2; 3-hydroxyacyl-CoA dehydratase 2 (HACD2); Protein-tyrosine phosphatase-like member B; 4.2.1.134; HACD2_MOUSE; 3-hydroxyacyl-CoA dehydratase 2; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HACD2 {ECO:0000303|PubMed:18554506, ECO:0000312|HGNC:HGNC:9640} |
|---|---|
| Function | Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in testis, spleen, prostate, colon and heart, followed by moderate expression in thymus, ovary, small intestine, peripheral blood leukocytes, liver, skeletal muscle and pancreas. Weakly detected in kidney, placenta, brain and lung |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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