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SPATA5L1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9BVQ7 |
| Other Accession | Q9BVQ7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 80710 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SPATA5L1 |
| Epitope Specificity | 221-320/753 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the AAA ATPase family. AFG2 subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SPATA5L1 is a 753 amino acid protein belonging to the AAA ATPase family and AFG2 subfamily. Single nucleotide polymorphisms (SNPs) present in SPATA5L1 at the glycine amidinotransferase (GATM)-SPATA5L1 locus have been found to correlate with glomerular filtration rate (GFR), having significant implications for kidney disease research. SPATA5L1 localizes to cytoplasm and exists as three alternatively spliced isoforms. The gene encoding SPATA5L1 maps to human chromosome 15q21.1. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and comprises about 3% of the human genome. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene. |
| Gene ID | 79029 |
|---|---|
| Other Names | AFG2B; DFNB119; NEDHLS; SPATA5L1; AFG2B_BOVIN; AFG2 AAA ATPase homolog B; Ribosome biogenesis protein SPATA5L1; Spermatogenesis-associated protein 5-like protein 1; 3.6.4.10; AFG2B_HUMAN; |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | AFG2B (HGNC:28762) |
|---|---|
| Function | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease- dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S- phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus {ECO:0000250|UniProtKB:D4A2B7} |
| Tissue Location | Expressed in both neurons and glia during embryonic and adult stages of brain development. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP96954
