癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LY6E Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q64253 |
| Other Accession | Q64253 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 14392 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse LY6E |
| Epitope Specificity | 31-80/136 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Contains 1 UPAR/Ly6 domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021] |
| Gene ID | 17069 |
|---|---|
| Other Names | Ly67; RIG-E; Sca-2; TSA-1; Tsa1; LY6E_MOUSE; Ly6e; Ly-6E; Stem cell antigen 2; Thymic shared antigen 1 (TSA-1); RIGE; SCA2; lymphocyte antigen 6 family member E; lymphocyte antigen 6 complex, locus E; retinoic acid induced gene E |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ly6e {ECO:0000312|MGI:MGI:106651} |
|---|---|
| Synonyms | Ly67, Sca-2, Tsa-1 |
| Function | GPI-anchored cell surface protein that regulates T- lymphocytes proliferation, differentiation, and activation (PubMed:8642345, PubMed:9575182). Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (PubMed:9575182). Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion (PubMed:32704094). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA) (PubMed:28679758). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta (PubMed:29500366). May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha- 3:beta-4-containing nAChRs maximum response (PubMed:26276394). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
| Tissue Location | Ubiquitously expressed in mouse adult tissues with maximal expression in the lung and the salivary gland. Expression is strikingly lower in the fetal tissues except for the placenta (PubMed:28679758). Present in thymus where its expression is observed in immature thymocytes and thymic stromal cells (PubMed:1531995). Also found on functionally active T-cells as well as B-cells and thymic dendritic cells (PubMed:2987354). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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